How CBD Oil Works to Kill Cancer?

Medical Cannabis for the Treatment of Depression
April 23, 2020

Forward-thinking countries in the past few years have recognized the healing benefits of CBD oil. This is the reason CBD oil (cannabidiol) is much talked about and available. 

Basically, the cannabis plant produces a resin that contains various substances. Some of these substances have medicinal value. These substances are called cannabinoids.

The two main cannabinoids having medicinal properties are:

  • Delta-9-tetrahydrocannabidiol (THC)
  • Cannabidiol (CBD)

There are some drugs available that have been derived from the cannabis plant. For example, Sativex is used for multiple sclerosis and Nabilone, but it is also in some cases used for sickness caused by chemotherapy sessions.

The potency of CBD oil might vary on the basis of the source and the extraction method as well. Extracting from the whole cannabis plant that has CBD-dominant content is said to have the highest yield of cannabinoids. This highly-potent CBD oil can interact with the body’s endocannabinoid system. The endocannabinoid system precisely affects everything related to the regulation of different body functions, such as mood, behavior, appetite, pain, sleep, energy, etc. Apart from this, the endocannabinoid system is also responsible for cell growth and Apoptosis.

And since cancer is developed due to the abnormal proliferation & mutation of cells, the medicinal cannabinoids in CBD oil is known for killing the abnormal cancer cells, especially when it is taken in the early stages of cancer. For a better understanding of how CBD cancer treatment works, you must know how CBD oil helps in Apoptosis.

How does CBD Oil help in Apoptosis?

Apoptosis is the natural process in the human body where the cells are destroyed as part of a certain organism’s growth. As we all know that cancer cells grow as an abnormal process in the body, they no longer acknowledge the body’s signals which in turn encourage or destroy the cell growth.

As these cells grow & divide, they start becoming more uncontrollable. And since they stop responding to Apoptosis, they tend to expedite the cell proliferation and ignore the other signals coming from the normal cells. This is the reason why the endocannabinoid system is considered to be an extremely important system in the human body because it also helps in modulating cell growth and death.

As the cancer cells reproduce faster than an endocannabinoid system can handle, the cancer cells start invading through the normal tissues and spread throughout the body. This process is known as metastasis.

The endocannabinoid system typically has two primary receptors:

  • CB1 receptors- mostly found in the brain
  • CB2 receptors- primarily found in the immune system.

THC is an active compound in the cannabis that binds to the CB1 receptors, and it is significantly responsible for mood, behavior, and other cerebral functions. On the other hand, CBD latches onto the CB2 receptors and gives signals to these receptors that there are invaders that are detrimental to the body.

The apoptotic process by these receptors is achieved with the help of de novo synthesis of ceramide & sphingolupid, which promotes the destruction of cells. 

Once they start binding together, the activation of receptor activation can then help the endocannabinoid system with signaling an anti-tumorigenic warning. This implies that it impairs cancer development by inhibiting reproduction, metastasis, and tumor angiogenesis.

Conclusion

Although further studies and clinical trials are being conducted to prove these claims, the cannabinoids in the CBD oil have undeniably helped cancer patients in one way or another. Also, it has been observed that chemotherapy patients turn to CBD oil for alleviating their post-chemo side effects such as nausea, fatigue, vomiting, inflammation, neuropathic pain, immune suppression, and loss of appetite.